All Of The Following Are True Of The Classical Pathway Of Complement Activation Except One. Select The One Answer That D oes Not Describe The Classical Pathway Of Complement Activation

General
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All Of The Following Are True Of The Classical Pathway Of Complement Activation Except One. Select The One Answer That D oes Not Describe The Classical Pathway Of Complement Activation

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All Of The Following Are True Of The Classical Pathway Of Complement Activation Except One. Select The One Answer That Does Not Describe The Classical Pathway Of Complement Activation

Answer:

The classical pathway of complement activation is an essential part of the immune system’s defense mechanism. Here are the characteristics that are true regarding the classical pathway, except for one:

  1. Initiation: The classical pathway is initiated by the binding of C1q to antigen-antibody complexes or directly to pathogens.

  2. Cascade Activation: Once C1q binds, it activates the C1r and C1s components, leading to the activation of subsequent complement components in a cascade.

  3. Cleavage of C3 and C5: The classical pathway leads to the cleavage of C3 and C5 components, triggering the formation of the membrane attack complex (MAC) to lyse target cells.

  4. Independent of Antibodies: Unlike the alternative pathway, the classical pathway requires antibody involvement for activation and is therefore antibody-dependent.

The statement that does not describe the classical pathway of complement activation is the one regarding its independence from antibodies. The classical pathway is indeed dependent on antibody-antigen complexes for initiation and activation.